MOTS-C 30mg

Overview

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a mitochondrial-derived peptide consisting of 16 amino acids. It is encoded within the mitochondrial genome and has emerged as a significant signaling molecule in metabolic research. MOTS-C is studied for its role in regulating cellular energy homeostasis, glucose metabolism, and metabolic adaptation.

As a mitochondrial-derived peptide, MOTS-C represents a novel class of signaling molecules that communicate mitochondrial status to the rest of the cell. Research indicates it plays a role in the regulation of metabolic processes by activating AMPK (AMP-activated protein kinase) and influencing the folate-methionine cycle.

Mechanism of Action

MOTS-C exerts its effects through several interconnected metabolic pathways, making it a valuable tool for studying cellular energy regulation and metabolic signaling:

Research indicates MOTS-C engages:

• AMPK activation, a master regulator of cellular energy homeostasis
• Folate-methionine cycle modulation, affecting one-carbon metabolism and de novo purine biosynthesis
• AICAR accumulation, linking mitochondrial signaling to AMPK-mediated metabolic regulation
• Nuclear translocation under metabolic stress, where it regulates adaptive gene expression via interaction with ARE-containing promoters

This multi-pathway signaling profile positions MOTS-C as a critical mediator of mitochondrial-nuclear communication and metabolic adaptation.

Research Applications

Metabolic Regulation

MOTS-C is extensively studied for its effects on glucose metabolism and insulin sensitivity. Research demonstrates that MOTS-C administration enhances glucose uptake in skeletal muscle cells through AMPK-dependent pathways, independent of insulin signaling. This makes it a key research tool for investigating metabolic homeostasis and glucose regulation.

Cellular Energy Homeostasis

As a mitochondrial-derived peptide, MOTS-C plays a central role in regulating cellular energy balance. Studies show it modulates the NAD+/NADH ratio, mitochondrial membrane potential, and oxidative phosphorylation efficiency, providing researchers with insights into mitochondrial-mediated energy regulation.

Exercise Physiology & Endurance

Research has identified MOTS-C as an exercise-induced mitokine. Circulating MOTS-C levels increase during physical activity in humans, suggesting a role in exercise-mediated metabolic benefits. Studies in murine models demonstrate improved physical performance capacity and enhanced skeletal muscle adaptation following MOTS-C administration.

Aging & Longevity Research

MOTS-C levels decline with age in both human and animal models, correlating with age-related metabolic dysfunction. Research investigates MOTS-C as a potential mediator of healthy aging through its effects on metabolic flexibility, cellular stress resistance, and mitochondrial function preservation.

Body Composition Research

Preclinical studies demonstrate MOTS-C prevents age-dependent and high-fat-diet-induced insulin resistance and obesity. Research explores its role in fat metabolism regulation, including effects on lipid oxidation, adipose tissue function, and overall energy expenditure.

Research Advantages

• 99%+ purity verified through HPLC analysis
• Canadian laboratory tested with full Certificate of Analysis
• 30mg per vial — optimized for in vitro and in vivo research protocols
• Lyophilized formulation for maximum stability and shelf life
• Ships from Toronto, Ontario with temperature-controlled packaging
• Free bacteriostatic water included with every order

IMPORTANT

This product is sold strictly for research, laboratory, and educational purposes only. It is not intended for human or veterinary use. Not a drug, supplement, food, or cosmetic. By purchasing, the buyer acknowledges that this product will only be used in accordance with applicable laws and regulations governing research materials.

Scientific References

1. Lee, C., et al. (2015). “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metabolism, 21(3), 443-454.
2. Kim, K.H., et al. (2018). “MOTS-c: an equal opportunity insulin sensitizer.” Journal of Molecular Medicine, 96(9), 869-872.
3. Reynolds, J.C., et al. (2021). “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nature Communications, 12(1), 470.
4. Zempo, H., et al. (2021). “Relation between plasma MOTS-c concentration and characteristics of resistance training in humans.” Medicine & Science in Sports & Exercise, 53(8S), 169.
5. Kim, S.J., et al. (2019). “Mitochondrial-derived peptides in aging and age-related diseases.” GeroScience, 41(3), 257-266.